Last updated 14 Jun 2004.
Fly Enhancer is continually updated with new features. Below is a history of Fly Enhancer in reverse-chronological order.
- 15 Mar 2004: Fly Enhancer is upgraded to a faster server, funded by the UC Berkeley Center for Integrative Genomics.
- 9 Mar 2002: Worm Enhancer and Plant Enhancer are launched.
- 15 Feb 2002: Fly Enhancer appears in Science's NetWatch.
- 12 Feb 2002: Gene names in graphics linked to GadFly.
- 8 Feb 2002: Clusters in graphics linked to detailed display showing the DNA sequence of the cluster with the sites highlighted in different colors.
- 8 Feb 2002: Detailed graphics added to show intron/exon structure of genes overlapping and encompassing clusters, including multiple transcripts.
- 28 Jan 2002: Fly Enhancer modified to allow searches for sequences up to 80 base pairs long.
- 8 Jan 2002: Graphics first appear on Fly Enhancer, depicting clusters which fall between genes and the genes that flank them.
- 20 Dec 2001: Fly Enhancer modified to report overlapping clusters as one merged cluster with the number of overlapping clusters reported, greatly reducing the amount of redundant output produced.
- 18 Dec 2001: Fly Enhancer web site goes from beta-testing to public status. Password restriction removed.
- 18 Dec 2001: PNAS paper published online.
- 7 Dec 2001: Fly Enhancer begins caching search results to enable repeated searches to appear almost instantaneously.
- 1 Dec 2001: Web version of Fly Enhancer is born with a new code base. New features in the Web version include: report of cluster results relative to the transcription start and stop of known and computed genes; a full report of genes falling within 30 kb of either side of the cluster rep; addition of a Boolean expression filtering option to the search parameters. Fly Enhancer adopts a more permissive definition of window, allowing sites with only one basepair in the window to be included in the cluster. Password restricted.
- Oct 2001: Fly Enhancer linked to annotation files; clusters reported with immediate flanking genes indicated. Partial Boolean feature enabled in search parameter.
- Dec 2000: Fly Enhancer search engine developed as a desktop research tool with a command-line interface. Fly Enhancer reported clusters which were then blasted against the Drosophila genome to find cluster location relative to known and computed genes. Fly Enhancer also returned the postion of each site in the cluster, the orientation of each site in the cluster, and the sequences of DNA flanking each site in the clusters, lined up in matrix form.